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    Croda International Plc c17 dihydro s1p
    <t>S1P</t> and Ceramide synthesis and metabolic pathway Ceramide is central hub of sphingolipid metabolism. There is three ways to produce ceramide, one from sphingomyelin (SM) by the action of the sphingomyelinases (SMase), one is the de novo biosynthesis by the action of the serine palmitoyl transferase (SPT) using serine and Palmitoyl-CoA as a substrate, following the production of dihydrosphingosine (dhSph) as an intermediate.dhSph is acylated by the action of ceramide synthase (CERS) to produce dihydroceramide and finally, ceramide is synthesized by the action of desaturase. Another one is salvage pathway by which recycling of free sphingosine produced from the degradation of pre-formed sphingolipids by the action of CERS. Sphingosine is phosphorylated by the enzyme SphKs to produce S1P. S1P plays a various cellular function through its five specific G-protein coupled receptors, i.e. S1P1 and S1P3. Of the S1P receptors, S1P1, S1P2 and S1P3 are expressed in sensory neurons, where S1P1 and S1P3 have been reported to play important roles in regulating nociceptor function. S1P1 and S1P3 are also expressed in both microglia and astrocytes. S1P: sphingosine 1-phosphate, SPPase: sphingosine phosphate phosphatase, SphKs: sphingosine kinases, CerS: ceramide synthase, SMS: SMase: sphingomyelinase SPT: serine palmitoyl transferase.
    C17 Dihydro S1p, supplied by Croda International Plc, used in various techniques. Bioz Stars score: 91/100, based on 339 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/c17+s1p/C17+Ceramide/pmc12059668-72-6-18
    Average 91 stars, based on 339 article reviews
    c17 dihydro s1p - by Bioz Stars, 2026-09
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    Images

    1) Product Images from "Metabolism of sphingolipids in a rat spinal cord stenosis model"

    Article Title: Metabolism of sphingolipids in a rat spinal cord stenosis model

    Journal: Biochemistry and Biophysics Reports

    doi: 10.1016/j.bbrep.2025.102025

    S1P and Ceramide synthesis and metabolic pathway Ceramide is central hub of sphingolipid metabolism. There is three ways to produce ceramide, one from sphingomyelin (SM) by the action of the sphingomyelinases (SMase), one is the de novo biosynthesis by the action of the serine palmitoyl transferase (SPT) using serine and Palmitoyl-CoA as a substrate, following the production of dihydrosphingosine (dhSph) as an intermediate.dhSph is acylated by the action of ceramide synthase (CERS) to produce dihydroceramide and finally, ceramide is synthesized by the action of desaturase. Another one is salvage pathway by which recycling of free sphingosine produced from the degradation of pre-formed sphingolipids by the action of CERS. Sphingosine is phosphorylated by the enzyme SphKs to produce S1P. S1P plays a various cellular function through its five specific G-protein coupled receptors, i.e. S1P1 and S1P3. Of the S1P receptors, S1P1, S1P2 and S1P3 are expressed in sensory neurons, where S1P1 and S1P3 have been reported to play important roles in regulating nociceptor function. S1P1 and S1P3 are also expressed in both microglia and astrocytes. S1P: sphingosine 1-phosphate, SPPase: sphingosine phosphate phosphatase, SphKs: sphingosine kinases, CerS: ceramide synthase, SMS: SMase: sphingomyelinase SPT: serine palmitoyl transferase.
    Figure Legend Snippet: S1P and Ceramide synthesis and metabolic pathway Ceramide is central hub of sphingolipid metabolism. There is three ways to produce ceramide, one from sphingomyelin (SM) by the action of the sphingomyelinases (SMase), one is the de novo biosynthesis by the action of the serine palmitoyl transferase (SPT) using serine and Palmitoyl-CoA as a substrate, following the production of dihydrosphingosine (dhSph) as an intermediate.dhSph is acylated by the action of ceramide synthase (CERS) to produce dihydroceramide and finally, ceramide is synthesized by the action of desaturase. Another one is salvage pathway by which recycling of free sphingosine produced from the degradation of pre-formed sphingolipids by the action of CERS. Sphingosine is phosphorylated by the enzyme SphKs to produce S1P. S1P plays a various cellular function through its five specific G-protein coupled receptors, i.e. S1P1 and S1P3. Of the S1P receptors, S1P1, S1P2 and S1P3 are expressed in sensory neurons, where S1P1 and S1P3 have been reported to play important roles in regulating nociceptor function. S1P1 and S1P3 are also expressed in both microglia and astrocytes. S1P: sphingosine 1-phosphate, SPPase: sphingosine phosphate phosphatase, SphKs: sphingosine kinases, CerS: ceramide synthase, SMS: SMase: sphingomyelinase SPT: serine palmitoyl transferase.

    Techniques Used: Synthesized, Produced, Cell Function Assay

    Quantitative analysis of changes in sphingolipid and ceramide levels over time in the spinal cord tissue subjected to spinal cord compression. Quantitative measurements of A) four sphingolipids (dhSph, dhS1P, Sph, and S1P) and B) six ceramides (Cer16:0, Cer18:0, Cer20:0, Cer22:0, Cer24:0, and Cer24:1) in the spinal cord of naïve rats and rats subjected to silicone compression for 1, 7, and 28 days. n = 4–6. A significant increase in S1P was observed on day 28 compared with the naïve controls. Conversely, the Cer24:1 level tends to increase on day1 and significantly decreased on days 7 and 28 compared to day 1. Statistical analyses were conducted using two-way ANOVA followed by Tukey's multiple comparison test. P < 0.05∗, <0.0001∗∗∗∗.
    Figure Legend Snippet: Quantitative analysis of changes in sphingolipid and ceramide levels over time in the spinal cord tissue subjected to spinal cord compression. Quantitative measurements of A) four sphingolipids (dhSph, dhS1P, Sph, and S1P) and B) six ceramides (Cer16:0, Cer18:0, Cer20:0, Cer22:0, Cer24:0, and Cer24:1) in the spinal cord of naïve rats and rats subjected to silicone compression for 1, 7, and 28 days. n = 4–6. A significant increase in S1P was observed on day 28 compared with the naïve controls. Conversely, the Cer24:1 level tends to increase on day1 and significantly decreased on days 7 and 28 compared to day 1. Statistical analyses were conducted using two-way ANOVA followed by Tukey's multiple comparison test. P < 0.05∗, <0.0001∗∗∗∗.

    Techniques Used: Comparison

    Quantitative analysis of changes in sphingolipid and ceramide levels in cerebrospinal fluid (CSF) subjected to spinal cord compression over time. Quantitative measurements of A) four sphingolipids (dhSph, dhS1P, Sph, and S1P) and B) six ceramides (Cer16:0, Cer18:0, Cer18:1, Cer20:0, Cer22:0, and Cer24:1) in the CSF of naïve rats and rats subjected to spinal cord compression for 1, 7, and 28 days. A significant decrease in Sph was observed on days 1 and 28 compared to the naïve controls. S1P also increased significantly after 7 days. Cer22:0 levels increased on day1, and the Cer24:1 level significantly increased on days 1 and 7 compared to naïve. n = 3–8. Statistical analyses were conducted using two-way ANOVA followed by Tukey's multiple comparison test. P < 0.05∗, <0.0001∗∗∗∗.
    Figure Legend Snippet: Quantitative analysis of changes in sphingolipid and ceramide levels in cerebrospinal fluid (CSF) subjected to spinal cord compression over time. Quantitative measurements of A) four sphingolipids (dhSph, dhS1P, Sph, and S1P) and B) six ceramides (Cer16:0, Cer18:0, Cer18:1, Cer20:0, Cer22:0, and Cer24:1) in the CSF of naïve rats and rats subjected to spinal cord compression for 1, 7, and 28 days. A significant decrease in Sph was observed on days 1 and 28 compared to the naïve controls. S1P also increased significantly after 7 days. Cer22:0 levels increased on day1, and the Cer24:1 level significantly increased on days 1 and 7 compared to naïve. n = 3–8. Statistical analyses were conducted using two-way ANOVA followed by Tukey's multiple comparison test. P < 0.05∗, <0.0001∗∗∗∗.

    Techniques Used: Comparison

    mRNA expression of the G-protein-coupled receptor for S1P (S1P1, S1P3) in the spinal cord after spinal cord compression. Quantitative PCR analysis revealed A) a significant increase in S1P1 mRNA expression throughout the experimental period (days 1, 7, and 28) and B) significant upregulation of S1P3 mRNA expression at day 1. n = 3–6. Statistical analyses were conducted using one-way ANOVA followed by Tukey's multiple comparison test. P < 0.05∗, <0.001∗∗∗.
    Figure Legend Snippet: mRNA expression of the G-protein-coupled receptor for S1P (S1P1, S1P3) in the spinal cord after spinal cord compression. Quantitative PCR analysis revealed A) a significant increase in S1P1 mRNA expression throughout the experimental period (days 1, 7, and 28) and B) significant upregulation of S1P3 mRNA expression at day 1. n = 3–6. Statistical analyses were conducted using one-way ANOVA followed by Tukey's multiple comparison test. P < 0.05∗, <0.001∗∗∗.

    Techniques Used: Expressing, Real-time Polymerase Chain Reaction, Comparison

    Related Articles

    other:


    Article Title: A Prokaryotic S1P Lyase Degrades Extracellular S1P In Vitro and In Vivo : Implication for Treating Hyperproliferative Disorders
    Article Snippet: S1P, C17-S1P, C17-sphingosine, C17-ceramide and 2E-hexadecenal were from Avanti Polar (Alabaster, AL, US).

    Article Title: Long chain base sphingosine kinase inhibitors
    Article Snippet: Deuterated (D7) S1P, S1P, sphingosine, C17 S1P and C17 sphingosine were purchased from Avanti Polar Lipids (Alabaster, Ala., USA).

    Article Title: Increased SPHK2 Transcription of Human Colon Cancer Cells in Serum-Depleted Culture: The Involvement of CREB Transcription Factor.
    Article Snippet: b Bioinformatics Section, Center for Advanced Medicine and Clinical Research,Nagoya University Hospital, Nagoya, Japan c Department of Hematology, Kanazawa Medical University, Kanazawa, Japan, d College of Life and Health Sciences, Chubu University, Kasugai, Japan, e Department of Drug Information, Gifu Pharmaceutical University, Gifu, Japan f Division of Molecular Carcinogenesis, Nagoya University Graduate School of Medicine, Nagoya, Japan, g Department of Microbiology and Molecular Biology, Nihon Pharmaceutical University, Saitama, Japan h Tokai Gakuin University, Kakamigahara, Japan

    Extraction:

    Article Title: Sphingosine Kinase Isoforms Regulate Oxaliplatin Sensitivity of Human Colon Cancer Cells through Ceramide Accumulation and Akt Activation
    Article Snippet: .. C6-ceramide (50 ng) and C17-S1P (50 ng) (Avanti Polar Lipid, Inc., Alabaster, AL), used as internal standards, were added during the lipid extraction step. ..



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    S1P and Ceramide synthesis and metabolic pathway Ceramide is central hub of sphingolipid metabolism. There is three ways to produce ceramide, one from sphingomyelin (SM) by the action of the sphingomyelinases (SMase), one is the de novo biosynthesis by the action of the serine palmitoyl transferase (SPT) using serine and Palmitoyl-CoA as a substrate, following the production of dihydrosphingosine (dhSph) as an intermediate.dhSph is acylated by the action of ceramide synthase (CERS) to produce dihydroceramide and finally, ceramide is synthesized by the action of desaturase. Another one is salvage pathway by which recycling of free sphingosine produced from the degradation of pre-formed sphingolipids by the action of CERS. Sphingosine is phosphorylated by the enzyme SphKs to produce S1P. S1P plays a various cellular function through its five specific G-protein coupled receptors, i.e. S1P1 and S1P3. Of the S1P receptors, S1P1, S1P2 and S1P3 are expressed in sensory neurons, where S1P1 and S1P3 have been reported to play important roles in regulating nociceptor function. S1P1 and S1P3 are also expressed in both microglia and astrocytes. S1P: sphingosine 1-phosphate, SPPase: sphingosine phosphate phosphatase, SphKs: sphingosine kinases, CerS: ceramide synthase, SMS: SMase: sphingomyelinase SPT: serine palmitoyl transferase.

    Journal: Biochemistry and Biophysics Reports

    Article Title: Metabolism of sphingolipids in a rat spinal cord stenosis model

    doi: 10.1016/j.bbrep.2025.102025

    Figure Lengend Snippet: S1P and Ceramide synthesis and metabolic pathway Ceramide is central hub of sphingolipid metabolism. There is three ways to produce ceramide, one from sphingomyelin (SM) by the action of the sphingomyelinases (SMase), one is the de novo biosynthesis by the action of the serine palmitoyl transferase (SPT) using serine and Palmitoyl-CoA as a substrate, following the production of dihydrosphingosine (dhSph) as an intermediate.dhSph is acylated by the action of ceramide synthase (CERS) to produce dihydroceramide and finally, ceramide is synthesized by the action of desaturase. Another one is salvage pathway by which recycling of free sphingosine produced from the degradation of pre-formed sphingolipids by the action of CERS. Sphingosine is phosphorylated by the enzyme SphKs to produce S1P. S1P plays a various cellular function through its five specific G-protein coupled receptors, i.e. S1P1 and S1P3. Of the S1P receptors, S1P1, S1P2 and S1P3 are expressed in sensory neurons, where S1P1 and S1P3 have been reported to play important roles in regulating nociceptor function. S1P1 and S1P3 are also expressed in both microglia and astrocytes. S1P: sphingosine 1-phosphate, SPPase: sphingosine phosphate phosphatase, SphKs: sphingosine kinases, CerS: ceramide synthase, SMS: SMase: sphingomyelinase SPT: serine palmitoyl transferase.

    Article Snippet: For the internal standards, C17 S1P, C17 dihydro S1P, C17:1 Sphingosine (Sph), C17:1 dihydrosphingosine (dhSph) and d18:1/17:0 Ceramide (Avanti Polar Lipids, Alabama) at 1.0 ng/mL (final concentration) were added.

    Techniques: Synthesized, Produced, Cell Function Assay

    Quantitative analysis of changes in sphingolipid and ceramide levels over time in the spinal cord tissue subjected to spinal cord compression. Quantitative measurements of A) four sphingolipids (dhSph, dhS1P, Sph, and S1P) and B) six ceramides (Cer16:0, Cer18:0, Cer20:0, Cer22:0, Cer24:0, and Cer24:1) in the spinal cord of naïve rats and rats subjected to silicone compression for 1, 7, and 28 days. n = 4–6. A significant increase in S1P was observed on day 28 compared with the naïve controls. Conversely, the Cer24:1 level tends to increase on day1 and significantly decreased on days 7 and 28 compared to day 1. Statistical analyses were conducted using two-way ANOVA followed by Tukey's multiple comparison test. P < 0.05∗, <0.0001∗∗∗∗.

    Journal: Biochemistry and Biophysics Reports

    Article Title: Metabolism of sphingolipids in a rat spinal cord stenosis model

    doi: 10.1016/j.bbrep.2025.102025

    Figure Lengend Snippet: Quantitative analysis of changes in sphingolipid and ceramide levels over time in the spinal cord tissue subjected to spinal cord compression. Quantitative measurements of A) four sphingolipids (dhSph, dhS1P, Sph, and S1P) and B) six ceramides (Cer16:0, Cer18:0, Cer20:0, Cer22:0, Cer24:0, and Cer24:1) in the spinal cord of naïve rats and rats subjected to silicone compression for 1, 7, and 28 days. n = 4–6. A significant increase in S1P was observed on day 28 compared with the naïve controls. Conversely, the Cer24:1 level tends to increase on day1 and significantly decreased on days 7 and 28 compared to day 1. Statistical analyses were conducted using two-way ANOVA followed by Tukey's multiple comparison test. P < 0.05∗, <0.0001∗∗∗∗.

    Article Snippet: For the internal standards, C17 S1P, C17 dihydro S1P, C17:1 Sphingosine (Sph), C17:1 dihydrosphingosine (dhSph) and d18:1/17:0 Ceramide (Avanti Polar Lipids, Alabama) at 1.0 ng/mL (final concentration) were added.

    Techniques: Comparison

    Quantitative analysis of changes in sphingolipid and ceramide levels in cerebrospinal fluid (CSF) subjected to spinal cord compression over time. Quantitative measurements of A) four sphingolipids (dhSph, dhS1P, Sph, and S1P) and B) six ceramides (Cer16:0, Cer18:0, Cer18:1, Cer20:0, Cer22:0, and Cer24:1) in the CSF of naïve rats and rats subjected to spinal cord compression for 1, 7, and 28 days. A significant decrease in Sph was observed on days 1 and 28 compared to the naïve controls. S1P also increased significantly after 7 days. Cer22:0 levels increased on day1, and the Cer24:1 level significantly increased on days 1 and 7 compared to naïve. n = 3–8. Statistical analyses were conducted using two-way ANOVA followed by Tukey's multiple comparison test. P < 0.05∗, <0.0001∗∗∗∗.

    Journal: Biochemistry and Biophysics Reports

    Article Title: Metabolism of sphingolipids in a rat spinal cord stenosis model

    doi: 10.1016/j.bbrep.2025.102025

    Figure Lengend Snippet: Quantitative analysis of changes in sphingolipid and ceramide levels in cerebrospinal fluid (CSF) subjected to spinal cord compression over time. Quantitative measurements of A) four sphingolipids (dhSph, dhS1P, Sph, and S1P) and B) six ceramides (Cer16:0, Cer18:0, Cer18:1, Cer20:0, Cer22:0, and Cer24:1) in the CSF of naïve rats and rats subjected to spinal cord compression for 1, 7, and 28 days. A significant decrease in Sph was observed on days 1 and 28 compared to the naïve controls. S1P also increased significantly after 7 days. Cer22:0 levels increased on day1, and the Cer24:1 level significantly increased on days 1 and 7 compared to naïve. n = 3–8. Statistical analyses were conducted using two-way ANOVA followed by Tukey's multiple comparison test. P < 0.05∗, <0.0001∗∗∗∗.

    Article Snippet: For the internal standards, C17 S1P, C17 dihydro S1P, C17:1 Sphingosine (Sph), C17:1 dihydrosphingosine (dhSph) and d18:1/17:0 Ceramide (Avanti Polar Lipids, Alabama) at 1.0 ng/mL (final concentration) were added.

    Techniques: Comparison

    mRNA expression of the G-protein-coupled receptor for S1P (S1P1, S1P3) in the spinal cord after spinal cord compression. Quantitative PCR analysis revealed A) a significant increase in S1P1 mRNA expression throughout the experimental period (days 1, 7, and 28) and B) significant upregulation of S1P3 mRNA expression at day 1. n = 3–6. Statistical analyses were conducted using one-way ANOVA followed by Tukey's multiple comparison test. P < 0.05∗, <0.001∗∗∗.

    Journal: Biochemistry and Biophysics Reports

    Article Title: Metabolism of sphingolipids in a rat spinal cord stenosis model

    doi: 10.1016/j.bbrep.2025.102025

    Figure Lengend Snippet: mRNA expression of the G-protein-coupled receptor for S1P (S1P1, S1P3) in the spinal cord after spinal cord compression. Quantitative PCR analysis revealed A) a significant increase in S1P1 mRNA expression throughout the experimental period (days 1, 7, and 28) and B) significant upregulation of S1P3 mRNA expression at day 1. n = 3–6. Statistical analyses were conducted using one-way ANOVA followed by Tukey's multiple comparison test. P < 0.05∗, <0.001∗∗∗.

    Article Snippet: For the internal standards, C17 S1P, C17 dihydro S1P, C17:1 Sphingosine (Sph), C17:1 dihydrosphingosine (dhSph) and d18:1/17:0 Ceramide (Avanti Polar Lipids, Alabama) at 1.0 ng/mL (final concentration) were added.

    Techniques: Expressing, Real-time Polymerase Chain Reaction, Comparison